Registration Dossier
Registration Dossier
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EC number: 203-677-2 | CAS number: 109-52-4
Endpoint summary
Administrative data
Description of key information
Several GLP and non-GLP studies equivalent to OECD guidelines 404 and 405 are available for pure valeric acid and a mixture of valeric acid and 2-methylbutyric acid.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin: pure valeric acid and isopentanoic acid (a mixture of 64% valeric acid and 36% 2 -methylbutyric acid) produced full-thickness necrosis after 3 minutes exposure to rabbit skin and > 24 hour observation time.
Eye: pure valeric acid and isopentanoic acid (a mixture of 64% valeric acid and 36% 2 -methylbutyric acid) produced severe irritation with some effects not being reversible within 21 days.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
According to CLP Annex VI valeric acid is classified as corrosive to the skin cat. 1B based on full-thickness necrosis produced after 3 minutes of exposure and > 1 hour observation time. Valeric acid is classified as corrosive and assigned H314. Hence, the risk of severe damage to eyes is considered implicit and H318 is not included in the label.
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