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Registration Dossier
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EC number: 203-677-2 | CAS number: 109-52-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1379
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2d Meets national standard methods with acceptable restrictions. Purity of test substance is not given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Method: other: see test conditions
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Valeric acid
- EC Number:
- 203-677-2
- EC Name:
- Valeric acid
- Cas Number:
- 109-52-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- pentanoic acid
- Details on test material:
- n-valeric acid, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: males: 227 g; female 186 g
Administration / exposure
- Details on dermal exposure:
- Test substance was applied on the clipped skin of the back under occlusive conditions over 24 hrs.
- Duration of exposure:
- Test substance was applied on the clipped skin of the back under occlusive conditions over 24 hrs.
- Doses:
- 2000, 4000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Details on study design:
- Test substance was applied on the clipped skin of the back under occlusive conditions over 24 hrs.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 4000 mg/kg: all 3 male animals died within 24 hours, all 3 female animals died within 48 hours.
2000 mg/kg: males and females: no death - Clinical signs:
- other: Clinical signs: irregular breathing, giddiness, atonia, narcotic-like behaviour, insensibility to pain, rough coat, diarrhea, exsiccation, hemafecia.
- Gross pathology:
- The dermal application caused necrosis. Macroscopic examination after 14 d: heart dilatation and venous congestions in moribund animals.
Any other information on results incl. tables
RS-Freetext:
LD50 >2000 mg/kg bw and < 4000 mg/kg bw
Mortality: 4000 mg/kg: all 3 male animals died within 24
hours, all 3 female animals died within 48 hours. 2000 mg/kg
males and females: no death
Clinical signs: irregular breathing, giddiness, atonia,
narcotic-like behaviour, insensibility to pain, rough coat,
diarrhea, exsiccation, hemafecia.
The dermal application caused necrosis.
Macroscopic examination after 14 d: heart dilatation and
venous congestions in moribund animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of n-valeric acid is >2000 mg/kg.
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