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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1981
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Data for the dermal route of exposure is quantifiable.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
Fyrol FR-2 was applied to 60 µl methanol solution to a 4-cm² area of shaved back. Following administration, the animals were held in individual metabolism.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Test substance purity not stated
- (14)C-TDCP in 60ul methanol solution was used (corresponding to 0.867mg/kg)
Radiolabelling:
yes
Remarks:
Carbon - 14

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: NIEHS breeding colony
- Weight at study initiation: 150-200 g
- Individual metabolism cages: yes

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: Methanol
Duration of exposure:
4 hours
Doses:
0.867 mg/kg
No. of animals per group:
At least three rats
Details on study design:
14C TDCP was applied dermally in 60ul of a methanol solution (0.867 mg/kg) to a 4 cm2 area of shaved dorsal skin of male Sprague-Dawley rats. At least 3 rats were used (as stated previously, this is all the information that was provided regarding the number of animals used). Faeces, urine and expired air were collected.

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
not specified
Absorption in different matrices:
It was not possible to determine the rate of absorption in this study, however it is noted that TDCP is rapidly absorbed through rat skin.

Applicant's summary and conclusion