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EC number: 237-159-2
CAS number: 13674-87-8
A LOAEL of 5 mg/kg/day was derived.
In a 2-year carcinogenicity study in which groups of 60 male and
60 female rats were fed diets containing TDCP to achieve dose levels of
0, 5, 20 and 80 mg/kg/day for 24 months, significantly greater mortality
was recorded for high dose males. There was a clear adverse effect on
body weight in the 80 mg/kg/day groups throughout the study, with body
weights at termination >20 % lower than controls. A significant
reduction in red blood cell parameters was noted for high-dose animals.
Absolute and relative kidney, liver and thyroid weights were also
increased in mid- and high-dose animals.
A LOAEL of 5 mg/kg/day (based on the hyperplasia, considered a
pre-neoplastic lesion, observed in the kidneys in all treated groups and
the testicular effects observed at this dose) can be derived from this
In a 90-day study to investigate the possible neurotoxicity of
TDCP in hens, doses of 0. 4, 20 and 100 mg/kg/day TDCP were administered
to hens. There were no mortalities in TDCP-treated birds. Under the
conditions of the test, there was no evidence of TDCP induced delayed
neurotoxicity. In an epidemiology study carried out in a TDCP
manufacturing plant as an adjunct to a mortality study, no adverse
health effects linked to TDCP exposure were determined.
No data are available on inhalation and dermal repeated dose
The above data do not suggest to classify TDCP for repeated dose toxicity
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