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EC number: 237-159-2
CAS number: 13674-87-8
TDCP was well absorbed by the oral route of exposure and based on
available studies, 100 % absorption will be assumed. In accordance with
the default values given in the TGD, 100 % absorption via the inhalation
route will also be assumed. An in vitro percutaneous absorption
study using human skin membranes was conducted to determine the
absorption following topical application of [14C]-TDCP. The
skin membranes were exposed to TDCP for 8 hours, mimicking a normal
working day. The mean total absorption was 15.4 %, 10.69 % and 6.0 %,
for doses 0.003, 0.01 and 0.12 mg/cm2, respectively. A value
of 15 % dermal absorption is taken forward to risk characterisation for
exposure scenarios where there is potential exposure to “neat” TDCP and
30 % dermal absorption is assumed for scenarios 3, 4 and 5, where there
is exposure due to handling of foam containing TDCP.
Distribution studies showed highest levels in the liver and kidney
and lung following oral, dermal and i.v. administration. Tissue
concentrations of either the parent compound or metabolites were always
low due to rapid excretion. Rapid and extensive (essentially 100 %)
oxidative metabolism, mainly to the metabolite bis
(1,3-dichloro-2-propyl) phosphate (BDCP almost 70% of metabolites),
occurred. Excretion was mainly via the urine (approx 50 %), but also
occurred via faeces and expired air.
Elimination was rapid and so no accumulation in the body is
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