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EC number: 237-159-2
CAS number: 13674-87-8
was provided to suggest that TDCP is a bacterial cell mutagen in vitro.
Positive responses were seen in the mutation assay, following metabolic
activation only. Some papers reviewed included positive data for
possible metabolites of TDCP. In mammalian cell studies, TDCP caused
mutations in mouse lymphoma L5178Y cells in the presence of metabolic
also caused an increase in the occurrence of chromosomal aberrations in
mouse lymphoma cells, again in the presence of metabolic activation.
However, in a chromosomal aberration study in CHO cells, no increase in
cells with chromosome aberrations or polyploidy were recorded.
In vivo, TDCP was not clastogenic in a mouse
micronucleus assay and was found not to induce unscheduled DNA synthesis
in studies conducted to OECD guidelines. Negative results were also
obtained in a second in vivo micronucleus assay and in an in vivo/in
vitrourine mutagenicity assay.
some evidence to suggest that TDCP is mutagenic in vitro. However, in
vivo, the mouse micronucleus assays were negative, results which were
further supported by a negative result in an in vivo/in vitro
unscheduled DNA synthesis assay.
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