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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
other: Screening test is similar to the preliminary test in OECD guideline for the testing of chemicals, No. 105, Water Solubility
Principles of method if other than guideline:
The solubility of the test substance is investigated in a combined screening test (which is similar to OECD TG 105) followed by LCMS analysis of solutions obtained in the screening test.
Key result
Medium:
n-octanol
Solubility:
290 g/L
Temp.:
23 °C
Remarks on result:
other: analysed using LCMS
Details on results:
Another fraction of the test sample resulted in lower octanol solubility of 200 g/L. This lower result was considered to be due to lack of the test substance.
Conclusions:
Under the study conditions, the octanol solubility of the test substance was determined to be 290 g/L at 23°C (Farnback, 2012).
Executive summary:

A study was conducted to determine the n-octanol solubility of the test substance, C16 TMAC (Purity: 95.6%) in a combined screening test using the slow stirring method and LCMS analysis, according to a method similar to OECD Guideline 105. Under the study conditions, the octanol solubility of the test substance was determined to be 290 g/L at 23°C (Farnback, 2012).

Description of key information

The solubility of the test substance in organic solvents was determined using the slow stirring method and LCMS analysis, according to a method that is similar to OECD Guideline 105 (Farnback, 2012).

Key value for chemical safety assessment

Additional information

290 g/L at 23°C