Registration Dossier
Registration Dossier
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EC number: 214-604-9 | CAS number: 1163-19-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicological and environmental factors involved in the selection of decabromodiphenyl oxide as a fire retardant chemical.
- Author:
- Norris et al.
- Year:
- 1 973
- Bibliographic source:
- Appl Pol Symp 22:195–219.
- Reference Type:
- publication
- Title:
- Toxicology and human health asessment of decabromodiphenyl ether
- Author:
- Hardy et al.
- Year:
- 2 009
- Bibliographic source:
- Critical Reviews in Toxicology 39(S3):1-44.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test conducted prior to international guidelines. However, performance was consistent with today's guidelines.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(pentabromophenyl) ether
- EC Number:
- 214-604-9
- EC Name:
- Bis(pentabromophenyl) ether
- Cas Number:
- 1163-19-5
- Molecular formula:
- C12Br10O
- IUPAC Name:
- bis(pentabromophenyl) ether
- Details on test material:
- Former commercial product known as FR-300-BA, composed of 77% BDE209, 22% NonaBDEs, and 0.8% OctaBDEs.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- corn oil
- Doses:
- see below
- No. of animals per sex per dose:
- see below
- Control animals:
- yes
Results and discussion
- Preliminary study:
- Intragastric intubation of a single dose of a 10% corn oil
suspension of FR-300-BA to female Sprague-Dawley rats
did not affect survival at dose levels of 126, 252, 500, 1000, or
2000 mg/kg. No indication of toxicity after intubation or during
the 14-day period was observed. No gross pathological
changes were observed at necropsy carried out on 1 rat/dose
level.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Executive summary:
Intragastric intubation of a single dose of a 10% corn oil suspension of FR-300-BA to female Sprague-Dawley rats did not affect survival at dose levels of 126, 252, 500, 1000, or 2000 mg/kg. No indication of toxicity after intubation or during the 14-day period was observed. No gross pathological changes were observed at necropsy carried out on 1 rat/dose level (Norris et al., 1973).
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