Registration Dossier
Registration Dossier
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EC number: 214-604-9 | CAS number: 1163-19-5
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - August 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to international guidelines and GLPs using the commercial product as test article.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bis(pentabromophenyl) ether
- EC Number:
- 214-604-9
- EC Name:
- Bis(pentabromophenyl) ether
- Cas Number:
- 1163-19-5
- Molecular formula:
- C12Br10O
- IUPAC Name:
- bis(pentabromophenyl) ether
- Details on test material:
- Test material was a composite of equal porportions of the commercial DecaBDE products of Albemarle Corp, Dead Sea Bromine Group, and Chemtura Corp.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 20 +-2 degrees C
Results and discussion
Effect concentrations
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Any other information on results incl. tables
Treatment |
Concentration (mg/L) |
Respiration Rate (mg O2/L/hr) |
Percent Inhibition |
Control 1 |
NA |
41.6 |
NA |
Control 2 |
NA |
41.6 |
NA |
3,5-dichlorophenol |
3 |
39.0 |
6.3 |
3,5-dichlorophenol |
15 |
12.8 |
69.2 |
3,5-dichlorophenol |
50 |
4.9 |
88.2 |
DecaBDE |
15 |
40.0 |
3.9 |
DecaBDE |
15 |
43.4 |
-4.3 |
DecaBDE |
15 |
40.0 |
3.9 |
NA: Not applicable.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Difference in respiration between the 2 controls < 15% differece established for the test.
- Conclusions:
- DecaBDE did not inhibit the respiration of activiated sewage sludge.
- Executive summary:
DecaBDE did not inhibit the respiration of activiated sewage sludge when tested at a concentration of 15 mg/L. The negative and positve controls performed as expected.
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