Bis(pentabromophenyl) ether

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1996-1997

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study performed according to international guidelines and GLPs.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

2002

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OPPTS 850.1300 (Daphnid Chronic Toxicity Test)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Octabromodiphenyl ether

IUPAC Name:

Octabromodiphenyl ether

Details on test material:

The commerical octabromodiphenyl ether was used as test article. In consultation with the UK, DecaBDE was not tested due to its extremely low water solubility (<0.1 ug/L) and difficult analysis.

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

yes

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Post exposure observation period:

no

Test conditions

Hardness:

see EU RAR

Test temperature:

see EU RAR

pH:

see EU RAR

Dissolved oxygen:

see EU RAR

Salinity:

see EU RAR

Nominal and measured concentrations:

up to 2 ug/L (solubility limit for octabromodiphenyl ether)

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

> 2 µg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: survival, reproduction, growth

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

DecaBDE is not expected to be chronically toxic to Daphnia at the limit of its solubility.

Executive summary:

EU RAR DecaBDE, pg 92: "A long-term Daphnia test has been carried out using octabromodiphenyl ether. No effects on survival, reproduction or growth were seen over 21 days at concentrations up to 2 µg/l (solubility limit) (see the assessment of that substance for further details). Taken as a whole, it is clear that the aquatic toxicity and bioaccumulation potential of the polybrominated diphenyl ethers (penta-, octa- and decabromodiphenyl ether) decreases with increasing bromination and therefore it is unlikely that decabromodiphenyl ether will show any toxic effects to invertebrates at concentrations below its solubility limit."