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EC number: 214-604-9 | CAS number: 1163-19-5
TA98, 100, 1535, 1537; reverse mutation
Wagner and Kling (1998) (a)
WP2 uvrA; reverse mutation
Wagner and Kling (1998)
Mammalian cellsin vitro
Mouse lymphoma cells
L5178Ytk+/tk-; forward mutation
McGregor et al. (1988)
Chinese hamster ovary cells
Mammalian cellsin vivo
Sprague Dawley rats
Cytogenetic evaluation of bone marrow
Norris et al. (1975)
(a) Conducted in compliance with the US Food and Drug Administration’sGood Laboratory Practice for Nonclinical Laboratory Studies(FDA, 2002), the US EPA’sGood Laboratory Practice Standards(EPA, 1989, 1996), the United Kingdom’sGLP Compliance Programme, the Japanese GLP Standards, and the OECD’sPrinciples on Good Laboratory Practice(OECD, 1998).
ND = not determined.
No cytogenic changes were observed in the bone marrow of rats (parents and offspring) undergoing a one-generation reproduction test using FR-300-BA at the highest dose tested, 100 mg/kg bw/d (Norris et al., 1975).
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