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EC number: 214-604-9 | CAS number: 1163-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
14 d, 13 wk, 2 year studies in rats and mice.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The results of Norris et al. (1973, 1974, 1975) demonstrate that the former lower purity form of DecaBDE is capable of causing changes in liver weight and hepatocytomegaly, probably due to enzyme induction, as supported by the subtle changes in CYP documented by Van der Ven et al. (2008). Though Van der Ven et al. (2008) concluded that the commercial form of BDE-209 caused an effect on the weights of the epididymis and seminal vesicle, Hardy et al. (2008) showed that there were no statistically significant differences for these endpoints, nor was there a visible dose response from these data (Hardy et al., 2008). When considered in toto with the absence of any histopathological changes in these tissues or with sperm parameters, Van der Ven et al.’s (2008) conclusions are not supported by their data. Finally, the NTP (1986) study demonstrated that dietary exposures did not cause any gross or microscopic pathological effects in rats or mice at doses up to 5% in the diet for 90 d. In their 2 year study at doses up to 5% of the diet, nonneoplastic effects reported in male rats were confined to the liver, spleen, and mandibular lymph nodes (NTP 1986). In female rats, the only nonneoplastic effect to increase with dose was an increase in nephropathy; however, this lesion was present in 84% of control animals and is a common age-related lesion occurring in this strain of rat. Degeneration of the eye was observed in low-dose female rats (30%; cf. controls and high-dose groups = 10%). The NTP (1986) did not consider this effect to be treatment related, because this effect has been correlated with exposure to artificial light due to cage placement, and as a result, US NTP’s long-term studies presently incorporate cage rotation into the study design. This 2-year study was conducted prior to US NTP instituting cage rotation as a part of their experimental protocols. In male mice, nonneoplastic lesions were observed in the liver, mandibular lymph node, and thyroid. Non-neoplastic lesions in female mice were limited to the mandibular lymph node. Notably, no test-article-related effect on mortality or body weight was detected in the NTP 2 year studies in both species. NTP estimated the doses in the 2 year study were: 1120 or 2240 mg/kg bw/d (male rats), 1200 or 2550 mg/kg bw/d (female rats), 3200 or 6650 mg/kg bw/d (male mice), and 3760 or 7780 mg/kg bw/d (female mice) at the low and high doses, respectively. These results indicate a NOAEL in repeated dose stuides of at least 1000 mg/kg bw/d for the commercial DecaBDE product.
Justification for classification or non-classification
DecaBDE has a NOAEL of at least 1000 mg/kg bw/d in repeatd doses studies. Classification is not required.
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