Registration Dossier
Registration Dossier
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EC number: 202-640-8 | CAS number: 98-13-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
Additional information
There are no reproductive toxicity data on trichloro(phenyl)silane or its hydrolysis product, phenylsilanetriol, so good quality data for the related substance trimethoxy(phenyl)silane have been used to assess the reproductive toxicity of trichloro(phenyl)silane.
Trichloro(phenyl)silane hydrolyses rapidly in contact with water (half-life <1 minute at pH 7), generating HCl and phenylsilanetriol. Trimethoxy(phenyl)silane (CAS 2996 -92 -1) hydrolyses more slowly at pH 7 (half-life ca. 0.4 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other methoxysilanes. The relevant hydrolysis products are methanol and phenylsilanetriol. Both parent materials therefore generate a common silanol hydrolysis product.
Short description of key information:
No reproductive toxicity data are available for trichloro(phenyl)silane, therefore good quality data for the related substance trimethoxy(phenyl)silane have been read-across.
A well reported oral combined repeated dose/reproductive and developmental screening study (Harlan, 2009), conducted according to the current guideline and in accordance with GLP, reported a NOAEL for reproductive effects at the highest tested dose of 500 mg/kg bw/day for trimethoxy(phenyl)silane. General systemic parental effects were reported at the lowest tested dose of 100 mg/kg bw/day.
Effects on developmental toxicity
Description of key information
No developmental toxicity data are available for trichloro(phenyl)silane, therefore good quality data for the related substance trimethoxy(phenyl)silane have been read-across.
A well reported oral combined repeated dose/reproductive and developmental screening study (Harlan, 2009), conducted according to the current guideline and in accordance with GLP, reported a NOAEL for developmental effects at the highest tested dose of 500 mg/kg bw/day for trimethoxy(phenyl)silane. General systemic parental effects were reported at the lowest tested dose of 100 mg/kg bw/day.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
Additional information
There are no developmental toxicity data on trichloro(phenyl)silane or its hydrolysis product, phenylsilanetriol, so good quality data for the related substance trimethoxy(phenyl)silane have been used to assess the developmental toxicity of trichloro(phenyl)silane.
Trichloro(phenyl)silane hydrolyses rapidly in contact with water (half-life <1 minute at pH 7), generating HCl and phenylsilanetriol. Trimethoxy(phenyl)silane (CAS 2996 -92 -1) hydrolyses more slowly at pH 7 (half-life ca. 0.4 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other methoxysilanes. The relevant hydrolysis products are methanol and phenylsilanetriol. Both parent materials therefore generate a common silanol hydrolysis product.
Justification for classification or non-classification
There are no data to suggest that trichloro(phenyl)silane should be classified for reproductive or developmental toxicity.
Additional information
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