Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1969
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not meet current guideline requirements for skin irritation/corrosion. The original report was not available for review.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
1969
Reference Type:
other company data
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data available.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloro(phenyl)silane
EC Number:
202-640-8
EC Name:
Trichloro(phenyl)silane
Cas Number:
98-13-5
Molecular formula:
C6H5Cl3Si
IUPAC Name:
trichloro(phenyl)silane
Details on test material:
No data.

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
No data.
Observation period:
No data.
Number of animals:
No data.

Results and discussion

In vivo

Other effects:
Highly corrosive. Causes severe burns.

Applicant's summary and conclusion

Interpretation of results:
highly corrosive
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The test substance was determined to be highly corrosive in a study which did not meet current guideline requirements for acute dermal toxicity. It does, however, add weight of evidence for trichloro(phenyl)silane toxicity.