Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not meet current guideline requirements for acute dermal toxicity. It does however add weight of evidence for trichloro(phenyl)silane toxicity.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report date:
1951

Materials and methods

Test guideline
Qualifier:
no guideline followed
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloro(phenyl)silane
EC Number:
202-640-8
EC Name:
Trichloro(phenyl)silane
Cas Number:
98-13-5
Molecular formula:
C6H5Cl3Si
IUPAC Name:
trichloro(phenyl)silane
Details on test material:
No details available.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No information available

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
0.9 mL/kg bw

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of 0.9 ml/kg was determined in a study which did not meet current guideline requirements for acute dermal toxicity in rabbits. It does, however, add weight of evidence for trichloro(phenyl)silane toxicity.