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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Information is available from reliable studies for all the required in vitro endpoints. The results for cytogenicity (in vitro and in vivo) come from two closely related substances. The in vitro cytogenicity study gave a positive result, the results of all other tests were negative.


Short description of key information:
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without activation in all strains tested (similar to OECD TG 471)
Cytogenicity in mammalian cells: read-across from analogous substance trimethoxyphenylsilane CAS 2996-92-1: positive in Chinese hamster lung fibroblasts (V79) cells with activation, negative without activation (OECD TG 473)
Mutagenicity in mammalian cells: negative in L5178Y mouse lymphoma cells (OECD TG 476)

In vivo:
Micronucleus assay inhalation study in rat:: read-across from analogous substance dimethoxymethylphenylsilane CAS 3027-21-2: Negative (micronucleus data from OECD TG 413)

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The available information for the substance indicates that, when tested, trichloro(phenyl)silane (CAS number 98 -13 -5) did not induce mutations in bacterial or mammalian cells. There is evidence that the substance would be clastogenic in vitro, as the related substance trimethoxyphenylsilane CAS 2996-92-1 induced chromosome aberrations in mammalian cells in the presence of activation. This result is not supported by evidence from another closely related substance, dimethoxymethylphenylsilane CAS 3027-21-2, which has been tested in a 14 day inhalation study in mice, with no increase in the incidence of micronuclei in bone marrow. It is concluded that classification for mutagenicity is not required.