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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

2-Methoxy-4-nitroaniline was tested after dermal and oral treatment of rats. 
After dermal treatment no adverse effects were observed at a dose of 2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
1 260 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Additional information

The oral LD 50 was determined separately for male and female animals. Female animals proved more sensitive and showed a LD50 of 1260 mg/kg bw while for male animals the LD 50 was 2000 mg/kg bw.

Dermal treatment of rats caused no adverse effects at a dose of 2000 mg/kg bw.

Toxicity after inhalation was not tested.

Justification for classification or non-classification

Classified R22, harmful if swallowed, according to the oral LD50 in female rats