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Description of key information

2-Methoxy-4-nitroaniline was tested after dermal and oral treatment of rats. 
After dermal treatment no adverse effects were observed at a dose of 2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
1 260 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Additional information

The oral LD 50 was determined separately for male and female animals. Female animals proved more sensitive and showed a LD50 of 1260 mg/kg bw while for male animals the LD 50 was 2000 mg/kg bw.

Dermal treatment of rats caused no adverse effects at a dose of 2000 mg/kg bw.

Toxicity after inhalation was not tested.

Justification for classification or non-classification

Classified R22, harmful if swallowed, according to the oral LD50 in female rats