4-nitro-o-anisidine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1982

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: limited documentation, non-GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

GLP compliance:

no

Remarks:

pre dates GLP

Test material

Test material information

Constituent 1

Reference substance name:

4-nitro-o-anisidine

EC Number:

202-588-6

EC Name:

4-nitro-o-anisidine

Cas Number:

97-52-9

Molecular formula:

C7H8N2O3

IUPAC Name:

2-methoxy-4-nitroaniline

Constituent 2

Reference substance name:

PNOA

IUPAC Name:

PNOA

Test animals / tissue source

Species:

rabbit

Strain:

Himalayan

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

100 mg per eye

Observation period (in vivo):

72 h

Number of animals or in vitro replicates:

3

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 72 h

Score:

0

Max. score:

0

Irritant / corrosive response data:

no effects

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Classification: not irritating