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EC number: 210-871-0 | CAS number: 624-92-0
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity studies, carried out according to OECD 216 and 217, give 28-day EC50 greater than 15,000 mg/kg soil dw for soil microorganisms whatever the test considered (nitrogen transformation or carbon transformation). The NOEC = 15,000 mg/kg soil dw can be used as a long term endpoint for PNEC derivation, according to guidance R.7C.
Key value for chemical safety assessment
- Short-term EC50 for soil microorganisms:
- 15 000 mg/kg soil dw
Additional information
In 2007, toxicity of DMDS to soil microorganisms has been investigated by Scheerbaum in two GLP studies.
The first study has been investigated through OECD Guideline 216 and concerned a nitrogen transformation test.
Soil microorganisms were exposed for 28 days to a solution of dimethyl disulfide at different nominal concentrations of 62 - 185 - 556 - 1667 - 5000 and 15000 mg/kg dw.
EC 50 - 28d determined was greater than 15000 mg/kg soil d.w. and NOEC - 28d was of 15000 mg/kg soil d.w.
In this study, DMDS caused only transient effects > 50 % deviation, inhibition as well as stimulation, on day 7 and 14 after application.
Four weeks post application, a slight stimulation > 25 % was found at higher tested concentration (15000 mg/kg soil d.w). Therefore, under normal conditions, DMDS is not expected to lead to any long detrimental effects on nitrogen transformation in soil when applied with maximum 15000 mg/kg DW.
The second study has been investigated through OECD Guideline 217 and concerned a carbon transformation test.
Soil microorganisms were exposed for 28 days to an aqueous solution of dimethyl disulfide TC at different nominal concentrations of 20 - 60 - 180 - 540 - 1620 - 4860 and 14580 mg/kg.
EC 50 - 28d determined was greater than 14580 mg/kg soil d.w.
In this study, DMDS caused only transient effects > 50 % inhibition on the day of application. At the end of the study, DMDS was only found in the highest applied test group.
7 days post application, a slight stimulation was found at higher dosage levels. 4 weeks post application, no effects were detected on glucose induced respiration rates in any dosage level. Therefore, under normal conditions, DMDS is not expected to lead to any long detrimental effects on carbon transformation in soil when applied with maximum 14580 mg/kg dw.
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