Registration Dossier
Registration Dossier
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EC number: 210-871-0 | CAS number: 624-92-0
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
In 2005, an acute toxicity study of DMDS to Bobwhite quail was carried out by Kirkpatrick according to EPA OPPTS 870.1300 and GLP requirements. Based on the results of this study, the LC50 of DMDS was 478 ppm when male and female Bobwhite quail were exposed to a vapor of the test article as a single, 4-hour, whole-body exposure. LC50 was of 512 ppm for males and of 449 ppm for females.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 342 mg/kg food
Additional information
DMDS is applied once per year as a soil fumigant under a virtually impermeable film (VIF) tarp and is rapidly volatilised to air from an untarped soil surface (DMDS has a vapour pressure of 3.0 x 103Pa at 20°C (Diepenhorst PC, 2005) and a Henry’s Law Constant of 105 Pa.m3.mole at 20°C (Diepenhorst PC, 2006b). There are no incurred residues above natural background levels found in crops planted in DMDS-treated soil. Thus investigation of the avian dietary toxicity of DMDS is not warranted.
Given the rapid volatilisation of DMDS to air from an untarped soil surface, investigation of the avian inhalation toxicity of DMDS is warranted. In an acute inhalation study the LC50of DMDS was 478 ppm when male and female Bobwhite quail were exposed to vapourduring a single, 4-hour, whole-body exposure (Kirkpatrick DT, 2006). This exposure period compares to a DMDS photochemical oxidative degradation half-life in air of ca. 30 minutes (Hamwijk C, 2007). Against this environmental profile, continued or repeated exposure of birds or their nest sites to DMDS is unlikely to occur.
In 2005, an acute inhalation toxicity study of DMDS to Bobwhite quail was carried out by Kirkpatrick according to EPA OPPTS 870.1300 and GLP requirements. Based on the results of this study, the LC50 of Dimethyl Disulfide was 478 ppm when male and female Bobwhite quail were exposed to a vapor of the test article as a single, 4-hour, whole-body exposure. LC50 was of 512 ppm for males and of 449 ppm for females. In 2006, an acute oral toxicity study of DMDS to Bobwhite quail was carried out by Gallagher and Beavers according to EPA OPPTS 850.2100 and GLP requirements. Based on the results of this study, the LD50 of Dimethyl Disulfide was 342 mg/kg bw
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