Registration Dossier
Registration Dossier
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EC number: 500-302-7 | CAS number: 113930-69-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sept/Oct 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Principles of method if other than guideline:
- Partition coefficient was determined from individual solubilities of water and n-octanol by stir flask. Stir flask method was chosen, because the surface tension is less than 60 mN/m at 21°C.
- GLP compliance:
- no
- Type of method:
- other: stir flask
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 3.6
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: method: individual solubility stir flask
- Conclusions:
- The partition coefficient log Pow was determined by the stir flask method as 3.6 at 25°C (pH 7).
- Executive summary:
The purpose of the analysis was to determine the partition coefficient of the substance according to the EU A8 Guideline.
The partition coefficient test determined individual solubilities of the substance in water and n-octanol by the stir flask method at 25°C and pH 7. The water solubility of the substance was determined by means of TOC. The solubility in n-octanol was determined by a visual assessment.
The logPow was calculated from:
Log P = Log n-Octanol presaturated with pH10 buffer Solubility (mg/L) / pH 7 buffer presaturated with n-octanol Solubility (mg/L)
Reference
The solubility value at 25°C for n-octanol is >900,000 mg/L.
The concentration of the substance in buffered water at 25°C was determined by TOC to be 194 mg/L.
Description of key information
The partition coefficient log Pow was determined by the stir flask method as 3.6 at 25°C (pH 7).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.6
- at the temperature of:
- 25 °C
Additional information
The partition coefficient test determined individual solubilities of the substance in water and n-octanol by the stir flask method at 25°C and pH 7. The water solubility of the substance was determined by means of TOC. The solubility in n-octanol was determined by a visual assessment.
The logPow was calculated from:
Log P = Log n-Octanol presaturated with pH10 buffer Solubility (mg/L) / pH 7 buffer presaturated with n-octanol Solubility (mg/L)
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