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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Sept-Oct 2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: non-GLP
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
24.07 g/L
Temp.:
25 °C
pH:
ca. 7

The guidelines recommend solubility studies to be conducted where the substance is in its neutral or minimally ionized state. The solubility test was conducted at pH 7, that is approximately 2 pH units below the mean pH at half point (pH 8.74). The pH of a 0.1% solution was measured at 10.5.

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The average result of the solubility test for BADGE-MXDA at 25°C in buffered pH 7 water using TOC analysis is 24.07 g/L. For flasks from days 1-5 the %RSD is 5.3. The solution pH changed from 6.96 to an average 10.8 during the course of the test period.
Executive summary:

The purpose of the analysis was to determine solubility of BADGE-MXDA by the flask method according to OECD 105.

The mean water solubility value at 25°C was determined as 24.07 g/L / 19.6 %.

Water solubility (g/L) = (average TOC (g/L) / Carbon (wt%) elemental analysis) x100

Water solubility % = (average TOC (g/L) / Theorectical maximum TOC (g/L)) x100

Description of key information

The water solubility value at 25°C was determined as 24.07 g/L or 19.6 %.

Key value for chemical safety assessment

Water solubility:
24.07 g/L
at the temperature of:
25 °C

Additional information

Water solubility was conducted by flask method in accordance with EU A6 OECD Guidelines for The Testing of Chemicals 105, July 27, 1995.

The solubility test for BADGE-MXDA at 25°C in buffered pH 7 water was performed using TOC analysis and elemental analysis.

The solubility at pH 10.8 was calulated via the formulae below:

Water solubility (g/L) = (average TOC (g/L) / Carbon (wt%) elemental analysis) x100

Water solubility % = (average TOC (g/L) / Theorectical maximum TOC (g/L)) x100