Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
respiratory sensitisation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Research study using recognised guideline techniques and experimental models, but lacking full data reporting. Data is sufficient for assessment.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Is toluene diamine a sensitizer and is there cross-reactivity between toluene diamine and toluene diisocyanate?
Author:
Vanoirbeek JAJ, De Vooght V, Synhaeve N, Nemery B & Hoet PHM
Year:
2009
Bibliographic source:
Toxicol.Sci. 109 (2): 256-64

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methyl-m-phenylenediamine
EC Number:
202-453-1
EC Name:
4-methyl-m-phenylenediamine
Cas Number:
95-80-7
Molecular formula:
C7H10N2
IUPAC Name:
4-methylbenzene-1,3-diamine

Results and discussion

Results:
Using a model for respiratory sensitisation (there is no guideline method) using dermal indusction and inttranasal challenge, TDA did not elicit any respiratory or inflammatory response.

Applicant's summary and conclusion

Conclusions:
These is no indication that TDA is a respiratory sensitiser.