Diphosphorus pentasulphide

Endpoint summary

Description of key information

Acute toxicity studies by the oral roure (rat) and dermal route (rabbit) are available.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

791 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

3 160 mg/kg bw

Additional information

Acute oral toxicity

 

Five male rats were gavaged with a single dose of the test material at dose levels of 215, 464, 1000 and 2150 mg/kg bw and observed for 14 days. At the 2150 mg/kg bw dose level,all rats were found dead six hours after dosing. At all levels the test substance caused the rats to become depressed and irritable. At dose levels of 464 and 1000 mg/kg bw, 2 out of 5 rats died. The acute oral LD50 in the rat was calculated to be 791 (467 -1350) mg/kg bw.

 

Acute dermal toxicity

 

The test substance was applied for 24 hours under occlusive conditions at dose levels of 1000, 2150, 4540 and 10000 mg/kg bw. Animals were observed for 14 days. At the 4640 mg/kg bw dose level the rabbits were observed to be moderately depressed after exposure to the test substance. At the 1000 and 2150 mg/kg bw dose levels, rabbits had mild to moderate necrosis at the application site, except for one rabbit at the 1000 mg/kg bw dose level, which was free from irritation. At the 454 mg/kg bw dose level, one rabbit had slight oedema and the remaining three had oedema, necrosis and severe erythema. At a dose level of 1000 mg/kg and 2150 mg/kg there were no mortalities. At dose levels of 4640 and 10000 mg/kg bw, there was 100% mortality. The acute dermal LD50 of the test substance was calculated to be 3160 mg/kg bw