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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1979
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Insufficiently documented data from literature

Data source

Reference
Reference Type:
publication
Title:
Metabolism of toxic doses of o-chlorobenzylidene malonitrile (CS) in the rabbits
Author:
Paradowski M
Year:
1979
Bibliographic source:
Pol. J. Pharmacol. Pharm. 31, 563-572

Materials and methods

Principles of method if other than guideline:
acute intravenious toxicity
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzaldehyde
EC Number:
201-956-3
EC Name:
2-chlorobenzaldehyde
Cas Number:
89-98-5
Molecular formula:
C7H5ClO
IUPAC Name:
2-chlorobenzaldehyde
Details on test material:
- Name of test material (as cited in study report): o-chlorobenzaldehyde
- Analytical purity: min. 98%, distilled freshly prior to use

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
DMSO
Doses:
4 dose levels (not further specified)
No. of animals per sex per dose:
4 animals in each group (no information on sex of the animals)
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
8.5 other: mg/kg
95% CL:
6.5 - 11.2

Applicant's summary and conclusion

Executive summary:

The LD50 value of 2-chlorobenzaldehyde in rabbits after intravenious administration and 24 hrs observation period was 8.5 mg/kg bw.

The study has been judged not to be reliable (RL3) due to insufficient documentation.