Registration Dossier
Registration Dossier
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EC number: 444-040-0 | CAS number: 52950-18-2
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Reference substance name:
- (2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid
- EC Number:
- 444-040-0
- EC Name:
- (2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid
- Cas Number:
- 52950-18-2
- Molecular formula:
- Hill formula: C8H7ClO3 CAS formula: C8H7CLO3
- IUPAC Name:
- (2R)-2-(2-chlorophenyl)-2-hydroxyacetic acid
- Details on test material:
- - test substance: (R)-2-Chloromandelic acid
- purity: 99.5%
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 25°C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Modular HPLC System with UV/vis detector.
- Type, material and dimension of analytical (guard) column: 250 x 3 mm Nucleosil 100-5 CN (Macherey & Nagel)
- Detection system: UV/vis detector
MOBILE PHASES
- Type: water 1 acetonitrile = 9:1 (v/v) with 0.1 vol% H3P04, pH = 2.2
- Experiments with additives carried out on separate columns: no data
- pH: 2.2
- Solutes for dissolving test and reference substances: no data
DETERMINATION OF DEAD TIME
- Method: The dead time of the HPLC-system was measured withformamide.
REFERENCE SUBSTANCES
- Identity: Acetanilide
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 40 mg of test item was weighed in a 100 ml volumetric flask and dissolved in water/acetonitrile = 9:1 (v/v). This solution was diluted 1:5 with waterlacetonitrile = 9:1 (v/v).
For calibration, small amounts of reference compounds were dissolved in 20 vol% acetonitrile (ultrasonic treatment) and the flask was made up to volume with water.
REPETITIONS
- Number of determinations: no data
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- < 17.78
- Type:
- log Koc
- Value:
- < 1.25
Results: Batch equilibrium or other method
- Transformation products:
- not measured
Any other information on results incl. tables
RS-Freetext:
log Koc < acetanilide (1.25) at 25 °C
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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