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Environmental fate & pathways

Hydrolysis

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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Version / remarks:
Cited as Directive 92/69/EEC, C.7
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Test substance: (R)-2-Chloromandelic acid
- Substance No.: SR94653 ,
- purity: 99,7 %

Study design

Analytical monitoring:
yes
Buffers:
The three buffer solutions (pH = 4.0, 7.0 and 9.0) were prepared using Titrisol reagents (Merck)
with a precision of 0.02 pH units for each solution. The batch numbers ofthe reagents were:
* pH4.0:0C112733,
* pH 7.0: 0C129522,
* pH 9.0: 00449130.
Details on test conditions:
TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: test tubes
- Lighting: none
Duration of testopen allclose all
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
984 - 1 010 mg/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
967 - 1 030 mg/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
998 - 1 030
Number of replicates:
2

Results and discussion

Transformation products:
not measured
Total recovery of test substance (in %)open allclose all
% Recovery:
100
pH:
4
Temp.:
50 °C
Duration:
5 d
% Recovery:
93
pH:
7
Temp.:
50 °C
Duration:
5 d
% Recovery:
100
pH:
9
Temp.:
50 °C
Duration:
5 d
Dissipation half-life of parent compoundopen allclose all
pH:
4
Temp.:
50 °C
Half-life:
> 1 yr
pH:
7
Temp.:
50 °C
Half-life:
> 1 yr
pH:
9
Temp.:
50 °C
Half-life:
> 1 yr
Details on results:
pH 4,7 and 9 at 50 °C: Degradation (in %): < 10 after 5day(s)

Any other information on results incl. tables


the test item can be considered as a hydrolytically stable compound at pH 4.0, 7.0 and 9.0, and its t1/2 at 25 °C was considered to be greater than 1 year.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes