Registration Dossier
Registration Dossier
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EC number: 444-040-0 | CAS number: 52950-18-2
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- Cited as Directive 92/69/EEC, C.7
- GLP compliance:
- yes
Test material
- Reference substance name:
- (2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid
- EC Number:
- 444-040-0
- EC Name:
- (2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid
- Cas Number:
- 52950-18-2
- Molecular formula:
- Hill formula: C8H7ClO3 CAS formula: C8H7CLO3
- IUPAC Name:
- (2R)-2-(2-chlorophenyl)-2-hydroxyacetic acid
- Details on test material:
- - Test substance: (R)-2-Chloromandelic acid
- Substance No.: SR94653 ,
- purity: 99,7 %
Constituent 1
Study design
- Analytical monitoring:
- yes
- Buffers:
- The three buffer solutions (pH = 4.0, 7.0 and 9.0) were prepared using Titrisol reagents (Merck)
with a precision of 0.02 pH units for each solution. The batch numbers ofthe reagents were:
* pH4.0:0C112733,
* pH 7.0: 0C129522,
* pH 9.0: 00449130. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: test tubes
- Lighting: none
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 984 - 1 010 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 967 - 1 030 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 998 - 1 030
- Number of replicates:
- 2
Results and discussion
- Transformation products:
- not measured
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 93
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 100
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Details on results:
- pH 4,7 and 9 at 50 °C: Degradation (in %): < 10 after 5day(s)
Any other information on results incl. tables
the test item can be considered as a hydrolytically stable compound at pH 4.0, 7.0 and 9.0, and its t1/2 at 25 °C was considered to be greater than 1 year.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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