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Numerous publications on observations in humans are available from the open literature. The results for skin sensitisation may only suggest irritation rather than contact allergy. No reports on occupational contact allergic reactions are available. This conclusion is supported by the independent evaluation of the MAK Commission for the Investigation of Health Hazards of Chemical Compounds in the work area (MAK, 46. Lieferung, 2009).

Dermal absorption was investigated for human volunteers indicating only 0.001 % absorption for CaNa2EDTA. It is concluded that systemic exposure via dermal route is negligible. This conclusion is supported by the independent evaluation of the MAK Commission for the Investigation of Health Hazards of Chemical Compounds in the work area (MAK, 46. Lieferung, 2009).