3-methoxyoestra-1,3,5(10)-trien-17-one

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: see remarks

Remarks:

sieving followed my microscopic evaluation

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

Mass median aerodynamic diameter:

3.2 µm

No.:

#1

Size:

< 4 µm

Distribution:

<= 6.82 %

Remarks on result:

other: spherical volume

No.:

#2

Size:

>= 4 - < 10 µm

Distribution:

<= 50.74 %

Remarks on result:

other: spherical volume

No.:

#3

Size:

>= 10 - < 100 µm

Distribution:

<= 42.44 %

Remarks on result:

other: spherical volume

No.:

#4

Size:

> 100 µm

Distribution:

<= 0 %

Remarks on result:

other: spherical volume

Accounting based on the total sample weight   Particle size (µm)   Spherical volume (%)  Mass fraction  >100 92.51  Sieve fraction   >100 0.00   Total (>100 µm)   92.51   Sieve fraction 10 -100 (inhalable)  3.18   Sieve fraction 4 -10 (thoracic)  3.80   Sieve fraction <4 (respirable)  0.51

Conclusions:

The MMAD (Mass Median Aerodynamic Diameter < 100μm) has a value of 3.20 μm as spherical particles.

Executive summary:

The MMAD (Mass Median Aerodynamic Diameter < 100μm) has a value of 3.20 μm as spherical particles.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100μm) has a value of 3.20 μm as spherical particles.