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EC number: 216-613-3 | CAS number: 1624-62-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Type of method:
- flask method
- Key result
- Water solubility:
- 1.8 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.9
- Remarks on result:
- other: mean value
- Conclusions:
- A water solubility of 1.8 mg/L was determined for Estron-Methylether.
- Executive summary:
The water solubility of Estron-Methylether is determined using the flask method according guidance A.6 of the European Community (Appendix to the guidelines 92/69/EWG, dated July 31,1992).
12 tubes containing a suspension of Estron-Methylether are kept in a water bath while stirring at 30°C. After three days the tubes are given in a water bath while stirring at 20°C ± 0.2 K. At the sampling time at days 1, 2, 3, 4, 7 and 10 (calculated from the start at 20°C) about 2 ml of the suspension are drawn up witll a syringe and centrifuged. After sampling the tubes
are put back while stirring into the water bath at 20°C and two sampies are analyzed at day 14, again. Each saturation experiment is made in duplicate.
The water solubility was determined after equilibration at 20°C and separation from the insoluble residues as 1.8 mg/L. According X-ray powder diffraction the starting material and the insoluble residues consist of the same solid state form.
Reference
Raw data of the solubility experiment
| t [d] | value 1 [g/L] | value 2 [g/L] | mean value [g/L] |
| 1 | 6.427E-4 | 6.656E-4 | 6.542E-4 |
| 2 | 5.378E-3* | 7.448E-4 | 7.448E-4* |
| 3 | 6.547E-4 | 2.144E-3 | 1.399E-3 |
| 4 | 5.589E-3* | 2.022E-3 | 2.022E-3* |
| 7 | 1.118E-3 | 2.905E-3 | 2.012E-3 |
| 10 | 1.851E-3 | 5.075E-4 | 1.179E-3 |
| 14 | 8.655E-4 | 3.742E-3 | 2.304E-3 |
*: not used for determination of the solubility (probably suspended particle)
Description of key information
The water solubility of Estron-Methylether is determined using the flask method according guidance A.6 of the European Community (Appendix to the guidelines 92/69/EWG, dated July 31,1992).
12 tubes containing a suspension of Estron-Methylether are kept in a water bath while stirring at 30°C. After three days the tubes are given in a water bath while stirring at 20°C ± 0.2 K. At the sampling time at days 1, 2, 3, 4, 7 and 10 (calculated from the start at 20°C) about 2 ml of the suspension are drawn up witll a syringe and centrifuged. After sampling the tubes
are put back while stirring into the water bath at 20°C and two sampies are analyzed at day 14, again. Each saturation experiment is made in duplicate.
The water solubility was determined after equilibration at 20°C and separation from the insoluble residues as 1.8 mg/L. According X-ray powder diffraction the starting material and the insoluble residues consist of the same solid state form.
Key value for chemical safety assessment
- Water solubility:
- 1.8 mg/L
- at the temperature of:
- 20 °C
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