Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation
Remarks:
no data
Type of information:
other: discussion based on literature data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Principles of method if other than guideline:
not reported
GLP compliance:
not specified
Type of study:
not specified
Species:
guinea pig
Strain:
not specified
Sex:
not specified

Mild irritation was seen when 1,1,2,2 -tetrachloro-1,2-difluoroethane was applied dermally to the skin of guinea pigs, no evidence of sensitisazion was seen. (Clayton et al, 1966).

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for skin sentitisation.
Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection and to this purpose,data deriving from scientific literature were rewieved.

ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondaty source of information.

The result of a skin sensitisation study is reported. Under the study, 1,1,2,2 -tetrachloro-1,2 -difluoroethane was applied dermally to the skin of guinea pings. According to the reference, no evidence of sensitisazion was seen. (Clayton et al, 1966).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The result of a skin sensitisation study in the guinea pig is reported.

The reported information derive from the ACGIH sheet for the substance 1,1,2,2 -tetrachloro-1,2 -difluoroethane.

According to the reference, no evidence of sensitisazion was seen.


Migrated from Short description of key information:
The result of a skin sensitisation study is reported. No evidence of sensitisazion was seen.

Justification for selection of skin sensitisation endpoint:
The reported reference is a secondary source which discusses the available literature data.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:
Migrated from Short description of key information:
No data available

Justification for classification or non-classification

Basing on the existing data for skin sensitisation, no classification as skin sensitizer is required according to Regulation (EC) No. 1272/2008.

No data on respiratory sensitisation is available.