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Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: oral
Remarks:
other: not specified
Type of information:
other: discussion based on literature data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
Author:
American Conference of Industrial Hygienists (ACGIH)
Year:
2008
Bibliographic source:
1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
Reference Type:
publication
Title:
Renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats.
Author:
Bucher JR
Year:
1996
Bibliographic source:
NTP Toxicology Program, Toxicology Report Series 45, NIH Pub 96-3935. Online at: http://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox045.pdf
Reference Type:
publication
Title:
Toxicity of the tetrachlorodifluoroethanes.
Author:
Greenberg LA & Lester D
Year:
1950
Bibliographic source:
Arch. Ind. Hyg. Occup. Med 2(3): 345-347
Reference Type:
publication
Title:
Fluorocarbon toxicity and biological action.
Author:
Clayton J W
Year:
1967
Bibliographic source:
Fluorine Chem Rev1:197-252

Materials and methods

Principles of method if other than guideline:
Discussion on literature data of subacute toxicty by oral route.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
IUPAC Name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
Constituent 2
Chemical structure
Reference substance name:
Tetrachloro-1,2-difluoroethane
EC Number:
200-935-6
EC Name:
Tetrachloro-1,2-difluoroethane
Cas Number:
76-12-0
Molecular formula:
C2Cl4F2
IUPAC Name:
1,1,2,2-tetrachloro-1,2-difluoroethane
Test material form:
other: no data
Details on test material:
Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Test animals

Species:
other: Rat, Mouse, Guinea pig, Rabbit

Results and discussion

Effect levels

Dose descriptor:
NOEL
Effect level:
125 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection. ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.

The results of several repeted dose toxicity studies are reported.

According to the reference, the NOEL of 125 mg/kg bw is derived from the 21 -day repeated dose toxicity study on rats.

1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the classification criteria for hazard classes related to repeated dose exposure by oral route according to Regulation (EC) No. 1272/2008.