Registration Dossier
Registration Dossier
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EC number: 200-935-6 | CAS number: 76-12-0
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-07-24 to 1991-09-20
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although no exhaustive description of the procedure is provided, the study is guideline-conform and it was conducted under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 1,1,2,2-tetrachloro-1,2-difluoroethane
- Analytical purity: 89.7%
Constituent 1
- Radiolabelling:
- no
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Cyprinus carpio
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- > 36 - < 106 dimensionless
- Remarks on result:
- other: Conc.in environment / dose:50 microg/L
- Type:
- BCF
- Value:
- > 29 - < 90 dimensionless
- Remarks on result:
- other: Conc.in environment / dose:5 microg/L
Applicant's summary and conclusion
- Conclusions:
- According to the source, the BCF of 1,1,2,2 -tetrachloro-1,2 -difluoroethane is between 36 and 106 at 50 microgr/L, and between 29 and 90 at 5 microgr/L.
- Executive summary:
The reported information derives by the Existing Chemicals Survey Program Conducted by the Japanese Government.
No exhaustive description of the procedure is provided but the study was conducted under GLP and it is to OECD 305 C "Bioaccumulation: Test for the Degree of Bioconcentration in Fish".
The BCF of 1,1,2,2 -tetrachloro-1,2 -difluoroethane was derived at two different concentrations.
According to the results, at 50 microgr/L the BCF is between 36 and 106, and at 5 microgr/L is between 29 and 90.
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