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Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: discussion based on literature data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
Author:
American Conference of Industrial Hygienists (ACGIH)
Year:
2008
Reference Type:
publication
Title:
Fully Halogenated Chlorofluorocarbons
Author:
World Health Organization (WHO)
Year:
1990
Bibliographic source:
In: Environmental Health Criteria 113, p 60. WHO, Geneva
Reference Type:
review article or handbook
Title:
Environmental and Occupational medicine.
Author:
Rom WN (Ed)
Year:
1992
Bibliographic source:
Environmental and Occupational medicine. 2nd edition, p 1299. Little Brown and Company, Boston, MA

Materials and methods

Principles of method if other than guideline:
not documented
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
IUPAC Name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
Constituent 2
Chemical structure
Reference substance name:
Tetrachloro-1,2-difluoroethane
EC Number:
200-935-6
EC Name:
Tetrachloro-1,2-difluoroethane
Cas Number:
76-12-0
Molecular formula:
C2Cl4F2
IUPAC Name:
1,1,2,2-tetrachloro-1,2-difluoroethane
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Results and discussion

Applicant's summary and conclusion

Executive summary:

Absorption, distribution, metabolism and excretion of 1,1,2,2 -tetrachloro-1,2 –difluoroethane are discussed under the ACGIH sheet for the substance.

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection, and to this purpose the available scientific data on substances are revised.

 

According to the reference, chlorofluorocarbons as 1,1,2,2 -tetrachloro-1,2 –difluoroethane, appear to be eliminated almost exclusively through the respiratory tract. Little, if any, chlorofluorocarbon or metabolite has ever been reported in urine and feces. 1,1,2,2 -tetrachloro-1,2 –difluoroethane is absorbed by the lung and undergoes little, if any, significant biotransformation.