Registration Dossier
Registration Dossier
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EC number: 220-150-2 | CAS number: 2643-07-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- other: BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- p-[(2-chloroethyl)ethylamino]benzaldehyde
- EC Number:
- 220-150-2
- EC Name:
- p-[(2-chloroethyl)ethylamino]benzaldehyde
- Cas Number:
- 2643-07-4
- Molecular formula:
- C11H14ClNO
- IUPAC Name:
- 4-[(2-chloroethyl)(ethyl)amino]benzaldehyde
- Details on test material:
- N-Ethyl-N-(2-chlorethyl)-p-amino-benzaldehyd (purity> 90 %)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous carboxymethylcellulose
- Doses:
- 50, 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 200 mg/kg bw
- Mortality:
- 200 mg/kg b.w.: all animals died
- Clinical signs:
- dyspnea, apathy, abnormal position, staggering, tremor, spastic gait, bite convulsions, tonic-clonic convulsions, salivation, poor general state
- Gross pathology:
- no intraabdominal substance deposition or agglutination
Any other information on results incl. tables
Mortality data:
Dose (mg/kg) |
No. of animals |
died within |
||||
1 hour |
1 day |
2 days |
7 days |
14 days |
||
200 |
5 males |
4/5 |
5/5 |
5/5 |
5/5 |
5/5 |
200 |
5 females |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
50 |
5 males |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
50 |
5 females |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
