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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute Toxicity:
- oral: LD50 = 78.5 mg/kg bw (rat);
- inhalation (IRT): LC50 > 1.68 mg/L air, 7 h (rat);
- dermal: 1630 mg/kg bw (rat);

Key value for chemical safety assessment

Additional information

Oral:

In the key study that was conducted equivalent or similar to OECD TG 401 groups of 5 rats per sex per dose received the test substance by gavage at the dose levels 31.6, 46.4, 68.1, 100, 147, 464, and 2150 mg/kg bw, and were observed for 14 days (BASF AG, 1980). An LD50 of 78.5 mg/kg bw was obtained.

 

Inhalation:

The acute inhalation toxicity of the test substance was evaluated in an Inhalation Risk Test (IRT) according to Smyth et al. (Am. Ind. Hyg. Ass. J. 23, 95-107, 1962) with 12 rats exposed to an atmosphere enriched with the test substance vapor at a concentration of 1.68 mg/L of air for a period of 7 hours (BASF AG, 1980). No mortality occurred, no signs of toxicity were observed and nothing abnormal was detected during dissection. An LC50 of > 1.68 mg/L/7 h was obtained.

 

Dermal:

In the key study that was conducted equivalent or similar to OECD TG 402 with the exception that an occlusive coverage was used, groups of 5 rats per sex per dose received the test substance at doses of 200, 400, 1000, 1470, 2000, 2610, 3160, 4640 mg/kg bw, and were observed for 14 days (BASF AG, 1980). An LD50 of 1630 mg/kg bw was obtained in female rats (males: > 4640 mg/kg bw).

Justification for classification or non-classification

EU classification according to Annex VI of the Directive 67/548/EEC:

- Toxic if swallowed, R25

- Harmful in contact with skin, R21

GHS classification according to Annex I 1272/2008 CLP (EU GHS):

- Oral route: Acute Category 3

- Dermal route: Acute Category 4