Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-150-2 | CAS number: 2643-07-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
Test material
- Reference substance name:
- p-[(2-chloroethyl)ethylamino]benzaldehyde
- EC Number:
- 220-150-2
- EC Name:
- p-[(2-chloroethyl)ethylamino]benzaldehyde
- Cas Number:
- 2643-07-4
- Molecular formula:
- C11H14ClNO
- IUPAC Name:
- 4-[(2-chloroethyl)(ethyl)amino]benzaldehyde
- Details on test material:
- N-Ethyl-N-(2-chlorethyl)-p-amino-benzaldehyd (purity > 90 %)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: The animals were starved for 15 - 20 h before application.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous carboxymethyl cellulose preparation
- Details on oral exposure:
- The application volume was 10 ml/kg.
- Doses:
- 31.6, 46.4, 68.1, 100, 147, 464, 2150 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Mortality was examined after 1 h and on days 1, 2, 7 and 14 after application
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 78.5 mg/kg bw
- Mortality:
- Mortality was examined after 1 h and on days 1, 2, 7 and 14 after application.
- Clinical signs:
- other: All groups except the lowest dose group (31.6 mg/kg bw) showed dyspnea, staggering, twitching and a poor general state. In addition, the dose groups showed the following symptoms: 31.6 mg/kg bw: nothing abnormal observed 46.4 mg/kg bw: excitation
- Gross pathology:
- Dead animals:
Heart (acute dilatation on the right, acute congestive hyperemia)
liver (broadened hepatic lobules), lung (spotted congestion, slight acute emphysema),
thymus (laminar hemorrhage)
Sacrificed animals:
nothing abnormal observed
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
