Registration Dossier
Registration Dossier
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EC number: 202-848-9 | CAS number: 100-40-3
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- other: publication
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature, no details
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 4-vinylcyclohexene
- EC Number:
- 202-848-9
- EC Name:
- 4-vinylcyclohexene
- Cas Number:
- 100-40-3
- Molecular formula:
- C8H12
- IUPAC Name:
- 4-ethenylcyclohex-1-ene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: mouse and rat
- Strain:
- other: B6C3F1 mice and F344 rats
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 30 days
- Frequency of treatment:
- daily
- Duration of test:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10-800 mg/kg/day
Basis:
no data
- No. of animals per sex per dose:
- no data
- Details on study design:
- VCH and epoxide metabolites injected; some animals pretreated with chloramphenicol or phenobarbital
- Statistics:
- no data
Results and discussion
Observed effects
-rats: 30 daily i.p. injections (800 mg/kg) of VCH failed to cause detectable ovotoxicity
-mice pretreated with chloramphenicol:69% inhibition of VCH epoxidation and protected mice from ovotoxocity.
- VCH epoxidation increased in phenobarbital pre-treated mice
-increasing VCH dose led to increase of circulating VCH epoxide (mice)
Applicant's summary and conclusion
- Conclusions:
- -VCH diepoxide is the most potent ovotoxic substance
- lack of ovotoxicity in VCH treated rats compared to mice because of slower rates of VCH biotransformation to epoxides and because of 20 fold higher rate of epoxide detoxification
- female B6C3F1 mouse : expression of P450IIA and P450IIB; female F344 rat: lack of related P450IIA mouse isoform and very low amounts of P450IIB
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
