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EC number: 202-848-9 | CAS number: 100-40-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment Accepted calculation method
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The identification of effluents from rubber vulcanization / Environ. Aspects Chem. Use Rubber Process. Oper., Conf. Proc.
- Author:
- Rappaport SM
- Year:
- 1 975
- Bibliographic source:
- U.S. EPA - Office of Toxic Substances, Washington (D.C. USA)
- Reference Type:
- publication
- Title:
- Air sampling and analysis in a rubber vulcanization area
- Author:
- Rappaport SM and Fraser DA
- Year:
- 1 977
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 38, 5, 205-210
- Reference Type:
- publication
- Title:
- Health aspects of the curing of synthetic rubbers
- Author:
- Fraser DA and Rappaport S
- Year:
- 1 976
- Bibliographic source:
- Environ. Health Perspect. 17, 45-53
Materials and methods
- Endpoint addressed:
- other: exposure to airborne concentration in rubber vulcanization industry during rubber stock curing process
- Principles of method if other than guideline:
- details: see publication
Test material
- Reference substance name:
- 4-vinylcyclohexene
- EC Number:
- 202-848-9
- EC Name:
- 4-vinylcyclohexene
- Cas Number:
- 100-40-3
- Molecular formula:
- C8H12
- IUPAC Name:
- 4-ethenylcyclohex-1-ene
- Test material form:
- other: vapor and airborne concentrations in the occupational environment during curing of rubber stock
Constituent 1
Method
- Details on study design:
- -quantitative and qualitative analysis by using gas chromatograhy coupled with mass spectrometry
generating vulcanization effluents from a stock in the lab (representative for a typical formulation cured by all major rubber companies)
-generation/collection of volantiles: 50g uncured rubber purged with nitrogen in stainless steel curing vessel, curing time 20 min, n=14 at temperatures 160°C -200°C (10°C steps); adsorption of released volantiles on activated charcoal
-sample elution from charcoal with 1 ml ethyl ether; eluate volumen reduced unter nitrogen to 50-75 µl
-2 nd part of the experiment: field air samples collected in the manufacturing area by using charcoal tube method; personnel sampling pumps were used and attached to structures of the locations; samples collected in a press room; 9 samples collected for 15-, 30-, and 45 minute intervalls over 6 hours (flow rate 1-1.5l/min) - Exposure assessment:
- measured
Results and discussion
- Results:
- Concentration of 4-vinyl 1-cyclohexene (mean / std. dev. (rel. std. dev.)) in the occupational environment during curing of rubber stock:
-Location 1: 71.0 ppb / 8.42 ppb (11.9%)
-Location 2: 92.3 ppb / 19.9 ppb (21.6%)
Any other information on results incl. tables
- acute effects have not been observed among employees (Fraser et al, 1976)
Applicant's summary and conclusion
- Conclusions:
- Conclusion from the publications: On the basis of current toxicological data, chronic health effects are also questionable at these exposure levels, but little information is available concerning the carcinogenic potential of the investigated compounds. Thus significant health effects cannot be ruled out.
- Executive summary:
4-vinyl 1-cyclohexene was measured in the air by using gas chromatograhy coupled with mass spectrometry in the occupational environment during curing of rubber stock. The authors came to the conclusion that on the basis of current toxicological data, chronic health effects are also questionable at these exposure levels, but little information is available concerning the carcinogenic potential of the investigated compounds. Thus significant health effects cannot be ruled out.
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