Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
other: publication
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature, no details

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1991
Reference Type:
publication
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-vinylcyclohexene
EC Number:
202-848-9
EC Name:
4-vinylcyclohexene
Cas Number:
100-40-3
Molecular formula:
C8H12
IUPAC Name:
4-ethenylcyclohex-1-ene
Details on test material:
no data
Radiolabelling:
not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
no further details, microsomes prepared from liver of the animals

Administration / exposure

Details on exposure:
no data
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
No. of animals per sex per dose / concentration:
no data
Positive control reference chemical:
not applicable
Details on study design:
no data
Details on dosing and sampling:
no data
Statistics:
no data

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data
Details on distribution in tissues:
no data
Details on excretion:
no data

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
male Wistar rat microsomes in vitro:
- ratio 4-vinylcyclohexene-1,2-epoxide : 4-vinylcyclohexene-7,8-epoxide-1,2-diol = 3.5:1
- trace amounts (0.001%) of vinylcyclohexene diepoxide

Applicant's summary and conclusion