Registration Dossier

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
other: publication
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature; no details

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1991

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-vinylcyclohexene
EC Number:
202-848-9
EC Name:
4-vinylcyclohexene
Cas Number:
100-40-3
Molecular formula:
C8H12
IUPAC Name:
4-ethenylcyclohex-1-ene
Details on test material:
no data

Test animals

Species:
other: rats and mice
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: no data
Details on inhalation exposure:
no data
Details on analytical verification of doses or concentrations:
no data
Duration of treatment / exposure:
4 months
Frequency of treatment:
6 hours /day
Doses / concentrations
Remarks:
Doses / Concentrations:
226 ppm
Basis:
no data
No. of animals per sex per dose:
no data
Details on study design:
no data
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
no data
Sacrifice and pathology:
no data
Other examinations:
no data
Statistics:
no data

Results and discussion

Results of examinations

Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
inhibition observed
Haematological findings:
effects observed, treatment-related
Description (incidence and severity):
leukocytosis, leukopenia, impaired hemodynamics

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion