Cyclohexane-1,4-dicarboxylic acid

Endpoint summary

Additional information

Acute oral toxicity

An acute oral toxicity study was conducted with groups of four male and four female rats administered the test material by gavage. Each animal received a single oral dose of 400, 800, 1600, or 3200 mg/kg of the test material administered as a 10% suspension in a guar gum vehicle. All animals at the 3200 mg/kg dose level and a single male at the 1600 mg/kg dose level died after exposure to the test material. Abnormal clinical signs evident during the study included slight to severe weakness, prostration, ataxia, cyanosis, labored breathing, dark eyes, and anorexia. The abnormal clinical signs were either transient or noted prior to death. All animals at the 400 and 800 mg/kg dose levels were clinically normal by 2 days after dosing. With the exception of slight weakness and anorexia noted on Days 1 and 2, the surviving animals at the 1600 mg/kg appeared clinically normal on the day following dosing. All animals which survived to termination of the study gained weight during both weeks of the study. The cause of death for rats which died after exposure to the test material was not determined. Animals which died following administration of the test material died within 24 hours of dosing and were not necropsied. The acute oral LD50 for this test material was calculated to be 1903 mg/kg for male rats and 2263 mg/kg for female rats. The acute oral LD50, calculated by combining the male and female mortality data, was 2075 mg/kg.

Acute dermal toxicity

An acute dermal toxicity study was performed with guinea pigs. Following test article application, slight skin irritation was observed at 24/48 hours, and no mortality was observed at 2 weeks after treatment. The acute dermal LD50 was considered to be greater than 1 g/kg, and no evidence of percutaneous absorption was observed following test article application.

Acute inhalation toxicity

Acute toxicity following inhalation exposure was not determined for this material.

Justification for classification or non-classification

Based on the oral LD50 calculated from the combined mortality data, the test material was classified as slightly toxic according to the criteria set forth by Hodge and Sterner (1949) and requires no toxicity classification as defined in the 18th Adaptation on the EC Classification, Packaging, and Labelling of Dangerous Substances.