Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

The substance 3,4 -dihydropyran was tested for its mutagenic potential based on the ability to induce point mutations in selected loci of several bacterial strains, i.e. Salmonella typhimurium and Escherichia coli, in a reverse mutation assay.

According to the results of the study, the test substance did not lead to an increase in the number of revertant colonies either without S-9 mix

or after adding a metabolizing system in two experiments carried out independently of each other (standard plate test and preincubation assay).

Thus, under the experimental conditions chosen, it is concluded that 3,4 -dihydropyran is not a mutagenic agent in a bacterial reverse mutation test in vitro. [BASF, 1999]


Short description of key information:
The substance 3,4-dihydropyran was not mutagenic in a bacterial reverse mutation assay (Ames test).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on negative results of the Ames tests, the criteria for classification according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 are not met.