Registration Dossier
Registration Dossier
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EC number: 203-810-4 | CAS number: 110-87-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The substance 3,4-dihydropyran was not mutagenic in a bacterial reverse mutation assay (Ames test).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
The substance 3,4 -dihydropyran was tested for its mutagenic potential based on the ability to induce point mutations in selected loci of several bacterial strains, i.e. Salmonella typhimurium and Escherichia coli, in a reverse mutation assay.
According to the results of the study, the test substance did not lead to an increase in the number of revertant colonies either without S-9 mix or after adding a metabolizing system in two experiments carried out independently of each other (standard plate test and preincubation assay).
Thus, under the experimental conditions chosen, it is concluded that 3,4 -dihydropyran is not a mutagenic agent in a bacterial reverse mutation test in vitro. [BASF, 1999]
Justification for classification or non-classification
Based on negative results of the Ames tests, the criteria for classification according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 are not met.
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