Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented non guideline study, no GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
yes
Remarks:
GC
Duration of exposure:
4 h
Concentrations:
analytical determined: 10.7 mg/l
nominal: 11.7 mg/l
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 10.7 mg/L air
Exp. duration:
4 h
Remarks on result:
other: highest concentration tested
Mortality:
no mortality was observed
Clinical signs:
accerlerated respiration, eyelid closure

Applicant's summary and conclusion

Conclusions:
3,4-dihydrpyran showed no toxic effects to rats after inhaltation (4 hrs) of 10.7 mg/kg bw.
Executive summary:

The acute toxicity after inhalation was investigated in a study performed with rats. Rats were exposed to air enriched with 3,4 -dihydropyran for 4 hours in a whole body inhalation chamber. Since no mortality was observed, the test substance needs not to be classified.