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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The LD50 value has been obtained by a secondary source (RTECS database) and it was not possible to assess the quality of the original source.

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Bollettino Chimico Farmaceutico
Year:
1987
Bibliographic source:
(Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy), 126,282. Available from RTECS database.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Only the LD50 value for acute oral toxicity in rats is reported.
GLP compliance:
not specified
Test type:
other: no data are available

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 600 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 in rats is 4600 mg/kg bw.
Executive summary:

After oral administration to rats, the acute LD50 for the similar substance ursodeoxycholic acid is 4600 mg/kg bw.