Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-542-6 | CAS number: 2458-08-4
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
To determinate the biodegradability of 12-ketochenodeoxycholic acid, experimental data on a similar substance (ursodeoxycholic acid) have been used in read-across. The test has been performed according to the OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test), the EU Method C.4-B (Determination of the "Ready" Biodegradability - Modified OECD Screening Test) and the EPA OPPTS 835.3110 (Ready Biodegradability).
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
Additional information
Basing on a similar substance (ursodeoxycholic acid), 12-ketochenodeoxycholic acid, although it is not used in a detergent, can be considered a surfactant as defined in Regulation 648/2004/EC: “any organic substance and/or mixture used in detergent, which has surface-active properties and which consist of one or more hydrophilic and one or more hydrophobic groups of such a nature and size that is capable of reducing the surface tension of water, and of forming spreading or adsorption monolayers at the water-air interface, and of forming emulsions and /or microemulsions and/or micelles, and of adsorption at water-solid interfaces”. Therefore, a surfactant shall be considered as biodegradable if the level of biodegradability is at least 60% within 28 days, irrespectively from 10-day window principle. In this test carried out according to OECD TG 301F, ursodeoxycholic acid reached 53.4% of degradation after the 10-d window, and 82% after 28 days. Therefore the substance, basing on a read-across approach, is considered readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
