Registration Dossier
Registration Dossier
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EC number: 219-542-6 | CAS number: 2458-08-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The original study report is not available, but the LD50 value is reported by a well recognized toxicological database: RTECS.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 1 987
- Bibliographic source:
- BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Milan, Italy). 126,282. Available from RTECS database.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No details on the followed guideline have been reported.
Test material
- Reference substance name:
- Ursodeoxycholic acid
- EC Number:
- 204-879-3
- EC Name:
- Ursodeoxycholic acid
- Cas Number:
- 128-13-2
- IUPAC Name:
- 3,7-dihydroxycholan-24-oic acid
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Subcutaneous LD50 in rabbits: > 2000 mg/kg bw.
- Executive summary:
The reported LD50 in rabbits by subcutaneous route of administration is higher than 2000 mg/kg bw.
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