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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1961
Report Date:
1961

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
BASF internal standardized method: Two rabbits per dose exposed orally to the test substance. Necropsy performed on the animals that died.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2,5-Dihydrofuran
- Purity: 94%
- Physical state: colorless clear iquid

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: Aqueous emulsion of Tragacanth
Doses:
0.4, 0.5, 1.0 mL/kg
No. of animals per sex per dose:
2
Control animals:
no
Details on study design:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 0.5 - <= 1 mL/kg bw
Based on:
test mat.
Mortality:
- No mortality observed in animals exposed to 0.4 and 0.5 mL/kg.
- All animals exposed to 1 mL/kg died, within 24 hours after exposure.
Clinical signs:
- Loss of apetite observed in animals exposed to 1.0 mL/kg
- In one animal, exposed to 0.4 or 0.5 mL/kg, a temporary lack of appetite, convulsive trembling, apathy and diarrhea were observed.
Gross pathology:
At the necropsy a histologically detectable extensive submucosal bleeding of the stomach was observed, in one of the animals that died
Other findings:
- Histopathology: Kidney damage was observed

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information