Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Principles of method if other than guideline:
According to internal BASF guideline
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2,5-Dihydrofuran
- Physical state: liquid

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
8 days
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
1

Results and discussion

In vivo

Results
Remarks on result:
other: Irreversible effects on the eye were observed 8 days after exposure
Irritant / corrosive response data:
After 1 hour: Chemosis, conjunctivae and slight corneal opacity were observed.
After 24 hours: Chemosis, conjunctivae and corneal opacity were observed.
After 8 days: Conjunctivae, slight corneal opacity and scars were observed.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information