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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Principles of method if other than guideline:
BASF internal method
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2,5-Dihydrofuran
- Substance No.: 77/746

Test animals

Species:
rabbit
Strain:
Vienna White
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: M.Gaukler, 6050 Offenbach
- Weight at study initiation: 2.69 and 2.74 kg, for females and males respectively
- Diet: ad libitum, Ssniff K standardiet for rabbits and guinea pigs (Intermast GmbH, Soest)
- Water: ad libitum

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: shaved back and flank (ca. 210 cm2)
- Type of wrap if used: aluminium foil, fixated with adhesive tape

REMOVAL OF TEST SUBSTANCE
- Washing: warm water or water/lutrol mixture. Dryed with pulp.
- Time after start of exposure: 24 hours
Duration of exposure:
24 hours
Doses:
400 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 400 mg/kg bw
Based on:
test mat.
Mortality:
No mortality observed.
Clinical signs:
Strong local irritation was observed in all exposed animals 24 hours after exposure. This remained until the end of the study and developed into scaling.
Gross pathology:
No effects observed.

Applicant's summary and conclusion