Registration Dossier
Registration Dossier
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EC number: 216-957-4 | CAS number: 1708-29-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- BASF internal method
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,5-dihydrofuran
- EC Number:
- 216-957-4
- EC Name:
- 2,5-dihydrofuran
- Cas Number:
- 1708-29-8
- Molecular formula:
- C4H6O
- IUPAC Name:
- 2,5-dihydrofuran
- Details on test material:
- - Name of test material (as cited in study report): 2,5-Dihydrofuran
- Substance No.: 77/746
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M.Gaukler, 6050 Offenbach
- Weight at study initiation: 2.69 and 2.74 kg, for females and males respectively
- Diet: ad libitum, Ssniff K standardiet for rabbits and guinea pigs (Intermast GmbH, Soest)
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: shaved back and flank (ca. 210 cm2)
- Type of wrap if used: aluminium foil, fixated with adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing: warm water or water/lutrol mixture. Dryed with pulp.
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- 400 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Strong local irritation was observed in all exposed animals 24 hours after exposure. This remained until the end of the study and developed into scaling.
- Gross pathology:
- No effects observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
